Power, mixing and flow dynamics of the novel Allegro™ stirred tank reactor

The development of new biopharmaceuticals relies on robust scale-up from small-scale screening studies to industrial bioreactors. Novel SUB designs can prove highly beneficial, although they lack the extensive characterisation traditional STRs. Pall Corporation’s Allegro™ STR 50-2000 L bioreactor range has a unique design square cross-section, with three wedge-shaped baffles. A scale-down 1 prototype (abbreviated A-STR) was developed for and compared standard cylindrical S-STR). Agreement power mixing number data that Allegro 200 indicated successful scale-down. In down-pumping mode, times in A-STR were approximately 53% lower than S-STR. However, up-pumping mode both configurations exhibited similar times. This study utilises provide quantitative commercial range, define operating parameters enhanced scalability, comparison geometry.